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Department of Biochemistry and Molecular Medicine

Department of Biochemistry and Molecular Medicine

John Hershey Ph.D.

John Hershey Ph.D.

Professor Emeritus
Briggs Hall,
Davis
e-mail

Recent/Current
Research Funding

National Institutes of Health

Graduate Group Affiliations

Biochemistry, Molecular, Cellular and Developmental Biology

Genetics

Microbiology

Research Interests

Dr. Hershey retired in 2004 and then closed his laboratory in 2010. Although no longer directing research, he remains active in the field of protein biosynthesis through an association with Dr. Christopher Fraser in the Dept. of Molecular and Cell Biology on the Davis campus. He also serves as a Co-Editor-in-Chief of a new journal called Translation, published by Landes Biosciences.

 

Representative Publications

Roobol, A., J. Roobol, M.J. Carden, M.E. Smith J.W. Hershey, A. Bastide, J.R. Knight, A.E. Willis and C.M. Smales (2013) The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3:  3b, 3i and 3h.  Biochem. J. PMID 24320561.

Villa, N., A. Do, J.W. Hershey and C.S. Fraser (2013)  Human Eukaryotic Initiation Factor 4G (eIF4G) Protein Binds to eIF3c, -d, and –e to Promote mRNA Recruitment to the Ribosome.  J. Biol. Chem. 288, 32932-32940.

Hershey, J.W.B., N. Sonenberg and M.B. Mathews (2012) Principle of translation control:  an overview. In: Protein Synthesis and Translational Control (JWB Hershey, N Sonenberg and MB Mathews, eds), pp 1-10, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.

Sokabe, M., C.S. Fraser and J.W.B. Hershey (2011) The Human Translation Initiation Multi-Factor Complex Promotes Methionyl-tRNAi Binding to the 40S Ribosomal Subunit.  Nucl. Acids Res. 40: 905-913.

Henderson, A., and J.W.B. Hershey (2011) The role of eIF5A in protein synthesis.  Cell Cycle 10 (21): 3517-3618.

Andaya, A., W. Jia, M. Sokabe, C.S. Fraser, J.W.B. Hershey and J.A. Leary (2011) Phosphorylation of Human Eukaryotic Initiation Factor 2g:  Novel Site Identification and Targeted PKC Involvement.  J. Proteome Res. 10, 4613-4623.

Henderson, C.A., and J.W.B. Hershey (2011) Translation Initiation Factor eIF5A Stimulates Protein Synthesis in Saccharomyces cerevisie.  Proc. Natl. Acad. Sci. USA 108, 6415-6419.

Ludwig, A.L., J.W.B. Hershey and P.J. Hagerman (2011) Initiation of translation of the FMR1 mRNA occurs predominantly through 5’end-dependent ribosomal scanning.  J. Mol. Biol. 407, 21-34.

 

Recent/Current Teaching

Upper division courses
  • 192 Internship in Biological Chemistry
  • 198 Group Study
  • 199 Special Study for Advanced Undergraduates
Graduate courses
  • 217 Molecular Genetics of Fungi (odd years)
  • 222 Mechanisms of Translational Control (even years)
  • BMB221C Molecular Biology
  • 298 Group Study
  • 299 Research
Professional courses for medical students
  • 410A Molecular and Cell Biology
  • 410B Cell Biology and Metabolism
  • 414 Molecular Medicine
  • 497 Tutoring in Biological Chemistry
  • 498 Group Study
  • 499 Research