Department of Biochemistry and Molecular Medicine

Department of Biochemistry and Molecular Medicine

Kumaresan, Pappanaicken

Assistant Researcher
Oak Park Research Building, Suite 2301
Sacramento, CA 95817
PH: 916-734-0905
e-mail

Recent/Current
Research Funding

National Institutes of Health

Graduate Group Affiliations

Biochemistry, Molecular, Cellular
and Developmental Biology

Cell and
Developmental Biology

Research Interests

My research focuses on two areas:

(1) identification of high affinity targeting ligands for pancreatic cancer imaging and therapy;

(2) development of small molecule bispecific immunoconjugates that can target cancer cells and not the normal cells for cancer immunotheray.

Representative Publications

Kumaresan, PR., Wang,Y., Saunders,M., Maeda,Y., Wang, X., and Kit S. Lam. Rapid Discovery of Death Ligands with One-Bead-Two-Compound Combinatorial Library Methods. Journal of ACS Combinatorial Science, 2011, DOI: 10.1021/co100069t.

Xiao W., Wang Y., Lau E., Luo J., Yao N., Shi S., Meza L., Tseng H., Maeda Y., Kumaresan PR., Liu R., Lightstone F., Takada Y., and Lam KS.. The Use of One-Bead one-Compound Combinatorial Library Technology to Discover high-affinity {alpha}v{beta}3 integrin and cancer targeting Arginine-Glycine-Aspartic Ligands with a build-in Handle. Mol Cancer Ther, 9(10): 2714-23, 2010.

Kumaresan PR, Luo J, Song A, Marik J, Lam KS. Evaluation of Ketone-Oxime Method for Developing Therapeutic On-Demand Cleavable Immunoconjugates. Bioconjug Chem, 19: 1313-1318, 2008.

Luo J, Zhang H, Xiao W, Kumaresan PR, Shi C, Pan CX, Aina OH, Lam KS. Rainbow Beads: A Color Coding Method to Facilitate High-Throughput Screening and Optimization of One-Bead One-Compound Combinatorial Libraries. J Comb Chem, 10: 599-604, 2008.

Natarajan A, Kumaresan PR, Denardo SJ, Denardo GL, Mirick G, Lam KS. Development of TNKase-specific cleavable peptide-linked radioimmunoconjugates for radioimmunotherapy. Bioorganic & Medicinal Chemistry Letters, 18: 4802-4805, 2008.

Lee JK, Mathew SO, Vaidya SV, Kumaresan PR, Mathew PA. CS1 (CRACC, CD319) Induces Proliferation and Autocrine Cytokine Expression on Human B Lymphocytes. J Immunol, 179: 4672-4678, 2007.

Recent/Current Teaching

Upper division courses

  • 192 Internship in Biological Chemistry
  • 198 Group Study
  • 199 Special Study for Advanced Undergraduates

    • Graduate courses

  • 209 Prostaglandins/Leukotrienes and Related Lipids (offered even years)
  • 214 Molecular Medicine
  • 217 Molecular Genetics of Fungi (odd years)
  • 222 Mechanisms of Translational Control (even years)
  • 230 Practical NMR
  • 231 Biomedical NMR (same as BPH 231)
  • 291 Human Genetics Seminar
  • 298 Group Study
  • 299 Research

    • Professional courses for medical students

  • 410A Molecular and Cell Biology
  • 499 Research

    • Honors and Awards

  • 2007 The manuscripts (#17) was commented by editor of "Bioconjugate chemistry", one of the leading journals in biological chemistry in the editor's section.
  • 2007 Chronic Myelogenous Leukemia Research Program (CMLRP); Exploration-Hypothesis Development Award (EHDA )
  • 2004 American Association of Immjunologist Junior Faculty Travel Award.
  • 2002 American Association of immunologists Junior Faculty Travel Award
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