Department of Biochemistry and Molecular Medicine

Department of Biochemistry and Molecular Medicine

Thomas Jue, Ph.D.

Professor
4323 Tupper Hall,
Davis Campus
PH: (530) 752-4569
e-mail

Recent/Current
Research Funding

Bayer Pharmaceutical

Graduate Group Affiliations

 

Biomedical Engineering

 

Biophysics

 

Nutrition Biology

 

Research Interests

Dr. Jue's research includes development and application of nuclear magnetic resonance spectroscopic/imaging techniques to study metabolic regulation in normal and tumor tissues in vivo. His current research focuses on 1) refining high resolution NMR techniques to investigate the cellular response to limiting oxygen and the control of oxidative phosphorylation in myocardium and skeletal muscle 2) developing chemical shift imaging technique to spatially map tissue oxygenation and metabolite levels in vivo 3) determining the structure and function of proteins, in particular myoglobin in the cell 4) assess the function of uncoupling protein in body weight regulation 5) observing embryogenesis in transgenic mice and 6) mapping angiogenesis and metastasis.

 

Representative Publications

Lin PC, Kreutzer U, Jue T. Myoglobin translational diffusion in myocardium and its implication on intracellular oxygen transport. J Physiol, 2007. 578: 595.

Jue, T. A voice over the smoke for academic freedom. Science, 2007. 315(5814): 937.

Lin, P. C., Kreutzer, U., Jue, T. Anisotropy and temperature dependence of myoglobin translational diffusion in myocardium: implication for oxygen transport and cellular architecture. Biophys J, 2007. 92(7): 2608-20.

Lin, P.C., Kreutzer,U., Jue,T. Contribution of myoglobin facilitated O2 diffusion in respiring tissue. The PHyyti, O. M., Olson, A. K., Ge, M., Ning, X. H., Buroker, N. E., Chung.

Y., Jue, T., Portman, M. A. Cardioselective dominant-negative thyroid hormone receptor (Delta337T) modulates myocardial metabolism and contractile efficiency. Am J Physiol Endocrinol Metab, 2008. 295(2): E420-7.hysiological Society, 69: 39.

Masuda, K., Truscott, K., Lin, P. C., Kreutzer, U., Chung, Y., Sriram, R., Jue, T. Determination of myoglobin concentration in blood-perfused tissue. Eur J Appl Physiol, 2008. 104(1): 41-8.

Ponganis, P. J., Kreutzer, U., Stockard, T. K., Lin, P. C., Sailasuta, N., Tran, T. K., Hurd, R., Jue, T. Blood flow and metabolic regulation in seal muscle during apnea. J Exp Biol, 2008. 211(Pt 20): 3323-32.

Sriram, R., Kreutzer, U., Shih, L., Jue, T. Interaction of fatty acid with myoglobin. FEBS Lett, 2008. 582(25-26): 3643-9.

Xie, H., Kreutzer, U., Jue, T. Oximetry with the NMR signals of hemoglobin 2009. Val E11 and Tyr C7. Eur J Appl Physiol.

Masuda, K., Takakura,H, Furuichi, Y., Iwase,S., Jue, T. NIRS measurement of O2 dynamics in contracting blood and buffer perfused hindlimb muscle. Adv Exp Med Biol. 2009.

 

Recent/Current Teaching

Upper division courses
  • 192 Internship in Biological Chemistry
  • 198 Group Study</ li>
  • 199 Special Study for Advanced Undergraduates
Graduate courses
  • 214 Molecular Medicine
  • 231 Biomedical NMR (same as BPH 231)
  • 291 Human Genetics Seminar
  • 298 Group Study</ li>
  • 299 Research
Professional courses for medical students
  • 410A Molecular and Cell Biology
  • 410B Cell Biology and Metabolism
  • 414 Molecular Medicine
  • 497 Tutoring in Biological Chemistry
  • 498 Group Study
  • 499 Research