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Department of Anesthesiology and Pain Medicine

Department of Anesthesiology and Pain Medicine

Yu-Fung Lin, Ph.D.

Associate Professor
Departments of Anesthesiology and
Physiology and Membrane Biology

Room 4144, Tupper Hall
One Shields Ave
Davis, CA  95616
Yu-Fung.Lin@ucdmc.ucdavis.edu
Tel (530) 754-4876
Fax (530) 752-5423

Publications

Lin, Y.F. The involvement of serotonergic neurons of the raphe nuclei in the control of blood pressure. Department of Zoology, National Taiwan University, Taipei, Taiwan, 1986. (M.S. Thesis)
  
Lin, A.M.Y., Pan, C.M., Lin, Y.F., Kuo, J.S. and Chai, C.Y. A cardioinhibitory area in the midbrain central tegmental field of cats. Brain Res. Bull. 18: 699-707, 1987.

Chai, C.Y., Lin, Y.F., Lin, A.M.Y., Pan, C.M., Lee, E.H. and Kuo, J.S. Existence of a powerful inhibitory mechanism in the medial region of caudal medulla--with special reference to the paramedian reticular nucleus. Brain Res. Bull. 20: 515-528, 1988. 

Chai, C.Y., Lin, Y.F., Wang, H.Y., Wu, W.C., Yen, C.T., Kuo, J.S. and Wayner, M.J. Inhibition of spinal reflexes by paramedian reticular nucleus. Brain Res. Bull. 25: 581-588, 1990.

Yen, C.T., Hwang, J.C., Su, C.K., Lin, Y.F., Yang, J.M. and Chai, C.Y. Differential actions of the median region of caudal medulla on autonomic nerve activities. Clin. Exp. Pharmacol. Physiol. 18: 743-751, 1991.

Chai, C.Y., Wu, W.C., Wang, S., Su, C.K., Lin, Y.F., Yen, C.T., Kuo, J.S. and Wayner, M.J. Coexistence of autonomic and somatic mechanisms in the pressor areas of medulla in cats. Brain Res. Bull. 29: 15-26, 1992.

Lin, Y.F., Browning, M.D., Dudek, E.M. and Macdonald, R.L. Protein kinase C enhances bovine α1β1γ2L GABAA receptor whole-cell currents expressed in L929 fibroblasts. Neuron 13: 1421-1431, 1994.

Lin, Y.F. Regulation of recombinant GABAA receptor function by Ca2+/phospholipid-dependent protein kinase (PKC) phosphorylation. Department of Physiology, University of Michigan Medical School, 1995. (Ph.D. Dissertation)

Lin, Y.F., Angelotti, T.P., Dudek, E.M., Browning, M.D. and Macdonald, R.L. Protein kinase C phosphorylation of the α1β1γ2L subunits of the GABAA receptor enhances whole-cell currents expressed in L929 fibroblasts. Mol. Pharmacol. 50: 185-195, 1996.

Lin, Y.F., Jan, Y.N. and Jan, L.Y. Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cell. EMBO J. 19: 942-955, 2000.

Minor, D.L., Lin, Y.F., Mobley, B.C., Avelar, A., Jan, Y.N., Jan, L.Y. and Berger, J.M. The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel. Cell 102: 657-670, 2000.

Ma, D., Zerangue, N., Lin. Y.F., Collins, A., Yu, M., Jan, Y.N. and Jan, L.Y. Role of ER export signals in controlling surface potassium channel numbers. Science 291: 316-319, 2001.

Yi, B.A., Lin, Y.F., Jan, Y.N. and Jan, L.Y. Yeast screen for constitutively active mutant G protein-activated potassium channels. Neuron 29: 657-667, 2001.

Yi, B.A., Minor, D.L., Lin, Y.F., Jan, Y.N. and Jan, L.Y. Controlling potassium channel activities: interplay between the membrane and intracellular factors. Proc. Natl. Acad. Sci. USA 98: 11016-11023, 2001.

Bichet, D., Lin, Y.F., Ibarra, C.A., Huang, C.S., Yi, B.A., Jan, Y.N. and Jan, L.Y. Evolving potassium channels via yeast selection reveals structural elements important for selectivity.  Proc. Natl. Acad. Sci. USA 101: 4441-4446, 2004.

Lin, Y.F., Raab-Graham, K., Jan, Y.N. and Jan, L.Y. Nitric oxide stimulation of ATP-sensitive potassium channels: Involvement of Ras/MAPK kinase pathway and contribution to neuroprotection. Proc. Natl. Acad. Sci. USA 101: 7799-7804, 2004. (YFL as corresponding author)

Mao, X., Chai, Y. and Lin, Y.F. Dual regulation of ATP-sensitive potassium channels by caffeine. Am. J. Physiol. Cell Physiol. 292: C2239-C2258, 2007. Epub 2007 Feb 15.

Misaki, N., Mao, X., Lin, Y.F., Suga, S., Li, G.H., Liu, Q., Chang, Y., Wang, H, Wakui, M. and Wu, J. Iptakalim, a vascular KATP channel opener, closes rat pancreatic Beta-cell KATP channels and increases insulin release. J. Pharmacol. Exp. Ther. 322: 871-878, 2007. Epub 2007 May 23.

Lin, Y.F. and Chai, Y. Modulation of the ATP-sensitive potassium channel by extracellular signal-regulated kinase-mediated phosphorylation. Neuroscience 152: 371-380, 2008. Epub 2008 Jan 9.

Chai, Y. and Lin, Y.F. Dual regulation of the ATP-sensitive potassium channel by activation of cyclic GMP-dependent protein kinase. Pflügers Arch.-European J. Physiol. 456: 897-915, 2008. Epub 2008 Jan 30.

Chen, T.Y., Lin, Y.F. and Zheng, J. Electrophysiological measurements of membrane proteins, T. Jue (ed), Fundamental Concepts in Biophysics, Vol. 1, Series: Handbook of Modern Biophysics, Humana Press, Totowa, NJ, 2009.

Chai, Y. and Lin, Y.F. Stimulation of neuronal KATP channels by cGMP-dependent protein kinase: Involvement of ROS and 5-hydroxydecanoate-sensitive factors in signal transduction. Am. J. Physiol. Cell Physiol. 298: C875-C892, 2010. Epub 2010 Jan 6. doi:10.1152/ajpcell.00196.2009


Chai, Y., Zhang, D.M. and Lin, Y.F. Activation of cGMP-dependent protein kinase stimulates cardiac ATP-sensitive potassium channels via a ROS/calmodulin/CaMKII signaling cascade.  PLoS ONE 6(3): e18191, 2011. doi:10.1371/journal.pone.0018191

Abstracts

Lin, Y.F., Lin, A.M., Pan, C.M., Lee, E.H., Kuo, J.S. and Chai, C.Y. A potent inhibitory mechanism in the medulla---the paramedian reticular nucleus.  The Second Joint Annual Conference of Biomedical Science, Taipei, Taiwan, Abstr.: 126, 1987.

Lin, Y.F. and Yen, C.T.  The involvement of serotonergic neurons of the nucleus raphe obscrus in the control of blood pressure.  The Second Joint Annual Conference of Biomedical Science, Taipei, Taiwan, Abstr.: 128, 1987.

Lin, Y.F., Yen, C.T. and Chai, C.Y.  The inhibitory effects of paramedian reticular nucleus on the somatic reflexes in cats.  The Third Joint Annual Conference of Biomedical Science, Taipei, Taiwan, 1988.

Lin, Y.F., Shih, R.S. and Chai, C.Y.  The inhibitory effects of paramedian reticular nucleus on the gastric movement in cats.  The Fourth Joint Annual Conference of Biomedical Science, Taipei, Taiwan, 1989.

Schafer, M.K.H., Lin, Y.F. and Watson, S.J. Characterization of proenkephalin heteronuclear RNA in individual nuclei in the rat brain. Soc. Neurosci. Abstr. 17: 604.7, 1991.

Lin, Y.F., Greenfield Jr., L.J., Browning, M.D. and Macdonald, R.L. Protein kinase C inhibits rundown of GABAA receptor currents in mouse cortical neurons and transfected L929 cells. Soc. Neurosci. Abstr. 18: 487.8, 1992.

Lin, Y.F., Browning, M.D. and Macdonald, R.L. Protein kinase C increases recombinant α1β1γ2L GABAA receptor currents expressed in L929 cells. Soc. Neurosci. Abstr. 19: 469.4, 1993.

Lin, Y.F., Browning, M.D. and Macdonald, R.L. Protein kinase C increases recombinant α1β1γ2L GABAA receptor currents expressed in L929 cells. 25th Annual Meeting, Society for Neurosci. Michigan Chapter, Abstr.: 5, 1994.

Lin, Y.F., Browning, M.D. and Macdonald, R.L. Protein kinase C increases recombinant α1β1γ2L GABAA receptor currents expressed in L929 cells. Fifth Annual Student Research Forum, Department of Physiology, University of Michigan, 1994.

Lin, Y.F., Browning, M.D., Dudek, E. M. and Macdonald, R.L. Protein kinase C enhances recombinant αΒβ1γ2L GABAA receptor single-channel currents expressed in L929 cells. Soc. Neurosci. Abstr. 20: 217.4, 1994.

Lin, Y.F. and Macdonald, R.L. Changes in single-channel properties of recombinant α1β1γ2L GABAA receptor currents expressed in L929 cells by protein kinase A phosphorylation. Soc. Neurosci. Abstr. 21: 19.10, 1995.

Lin, Y.F., Kapur, J. and Macdonald, R.L. Regulation of GABAA receptor single-channel currents by protein kinase A in acutely dissociated rat hippocampal dentate granule cells. Soc. Neurosci. Abstr. 22: 762.3, 1996.

Lin, Y.F. and Macdonald, R.L. Single-channel kinetic properties of the GABAA receptor in acutely dissociated rat hippocampal dentate granule cells. Soc. Neurosci. Abstr. 23: 7.9, 1997.

Lin, Y.F., Jan, Y.N. and Jan, L.Y. Protein kinase A-mediated phosphorylation alters the single-channel properties of truncated ATP-sensitive potassium (KATP) channel currents transiently expressed in HEK293 cells. Soc. Neurosci. Abstr. 24: 792.7, 1998.

Lin, Y.F., Jan, Y.N. and Jan, L.Y. Nitric oxide activates ATP-sensitive potassium (KATP) channel currents transiently expressed in HEK293 cells. Soc. Neurosci. Abstr. 26: 685.10, 2000.

Lin, Y.F., Jan, Y.N. and Jan, L.Y. Ras signaling pathway is involved in the nitric oxide-mediated modulation of ATP-sensitive potassium channel function. Biophysics Soc. Abstr. 82: 2902, 2002.

Lin, Y.F. Functional modulation of the ATP-sensitive potassium channel by mitogen-activated protein kinase in HEK293 cells.  Soc. Neurosci. Abstr. 30: 851.8, 2004.

Xao, X., Chai, Y. and Lin, Y.F. Stimulation of ATP-sensitive potassium channels by caffeine.  Soc. Neurosci. Abstr. 31: 609.6, 2005.

Chai, Y. and Lin, Y.F. Regulation of the ATP-sensitive potassium channels by cyclic GMP-dependent protein kinase.  Soc. Neurosci. Abstr. 32: 530.7, 2006.

Lin, Y.F. and Chai, Y. Dual regulation of the ATP-sensitive potassium channel mediated by cyclic GMP-dependent protein kinase.  FASEB J. 21: A540, 2007.

Mao, X. and Lin, Y.F. Calcium-dependent functional modulation of the ATP-sensitive potassium channel.  Soc. Neurosci. Abstr. 33: 43.8, 2007.

Chai, Y. and Lin, Y.F. Differential regulation of ATP-sensitive potassium channels by cyclic GMP-dependent protein kinase.  Soc. Neurosci. Abstr. 33: 43.9, 2007.

Lin, Y.F. Regulation of ATP-sensitive potassium channels by protein kinase G-dependent signaling.  Gordon Research Conference on Ion Channels, 2008.

Lin, Y.F. and Chai, Y. The Role of reactive oxygen species in the regulation of the ATP-sensitive potassium channels by cyclic GMP-dependent protein kinase.  Beijing Joint Conference of Physiological Sciences, Beijing, China, Oct. 19-22, 2008. (YFL is the recipient of an APS Travel Award to attend this meeting and was chosen for a platform presentation)

Chai, Y. and Lin, Y.F. The role of cyclic GMP-dependent protein kinase in the modulation of vascular ATP-sensitive potassium channels.  Soc. Neurosci. Abstr. 34, 2008.

Lin, Y.F. and Chai, Y. Regulation of neuronal KATP channels by signaling elicited by cGMP-dependent protein kinase activation. Biophysical Society Annual Meeting, 2009.